Systemic Sclerosis Presenting with Simultaneous Retinal Vasculitis in One Eye and Optic Neuritis in the other along with Severe Immune Haemolytic Anaemia Keywords: Systemic sclerosis, Retinal vasculitis, Optic neuritis, Autoimmune haemolytic anaemia

Systemic Sclerosis (SSc) is a connective tissue disorder which involves multiple systems in a chronic progressive manner. Micro–angiopathic haemolytic anaemia is a distinguished feature of “scleroderma renal crisis”, which is manifested by severe hypertension, a rapidly progressing renal dysfunction and hyperreninaemia and is seen in patients with an early, diffuse form of the disease. A nervous system involvement is rare, though entrapment neuropathies have been reported. Who presented with a sequential loss of vision in both eyes; due to retinal vasculitis in right eye and optic nerve demyelination in the left eye. She also had severe Coombs’ negative haemolytic anaemia in absence of any renal dysfunction or hypertension. Both the ophthalmologic and the haematologic manifestations are very rare and both responded well to oral prednisolone therapy. We are presenting a case of a 40 year old female with typical multisystem involvement in systemic sclerosis. [table/Fig-1]: Ophthalmoscopy revealed evidence of retinal vasculitis in her right eye manifested by superficial retinal hemorrhages, cotton wools spot, and retinal venous dilatation [table/Fig-2]: Thick patch of skin below her right eye www.jcdr.net Avijit Moulick et al., Systemic Sclerosis Presenting with Simultaneous Optic Neuritis, Retinal Vasculitis and Immune Haemolytic Anemia Journal of Clinical and Diagnostic Research. 2013 Dec, Vol-7(12): 2978-298